Oral administration of marine collagen peptides prepared from chum salmon (Oncorhynchus
keta) improves wound healing following cesarean section in rats
Sammanfattning
Background: The goal of the present study was to investigate the wound-healing potential of
marine collagen
peptides (MCPs) from chum salmon skin administered to rats following cesarean section (CS).
Methods: Ninety-six pregnant Sprague-Dawley rats were randomly divided into four groups: a vehicle
group
and three MCP groups. After CS, rats were intragastrically given MCPs at doses of 0, 0.13, 0.38, 1.15
g/
kg*bw, respectively. On postoperative days 7, 14, and 21, the uterine bursting pressure, skin tensile
strength,
hydroxyproline (Hyp) concentrations, and histological and immunohistochemical characteristics of
the scar
tissue were examined.
Results: In the MCP groups, the skin tensile strength, uterine bursting pressure, and Hyp were
significantly
higher than those in the vehicle group at all three time points (p <0.05). The formation of capillary,
fibroblast, and collagen fiber, the expression of platelet-endothelial cell adhesion molecule-1, basic
fibroblast
growth factor, and transforming growth factor beta-1 were increased in the MCP groups (p < 0.05).
Conclusion: MCPs could accelerate the process of wounding healing in rats after CS.